HuagongsheHuagongshe Chemistry Print Report · For research reference only
7,8-Dimethoxy-3-[3-(methylamino)propyl]-1,3-dihydro-2H-3-benzazepin-2-one → Ivabradine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7,8-Dimethoxy-3-[3-(methylamino)propyl]-1,3-dihydro-2H-3-benzazepin-2-one | HCID 66657736 | — |
| Reactant | (75)-3,4-Dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde | HCID 87093223 | — |
| Product | Ivabradine | HCID 132999 | — |
Reaction Steps
By proceeding as in Example 7, starting from (75)-3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-triene-7-carbaldehyde and 7,8-dimethoxy-3-[3-(methylamino)propyl]-1,3-dihydro-2H-3-benzazepin-2-one, a compound is obtained which is hydrogenated by following the procedure described in patent specification EP 0 534 859 (Example 1, Step D) to yield ivabradine base, which is then converted into its hydrochloride by following the procedure described in patent specification EP 0 534 859 (Example 2, Step E).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097720B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-d16701517cb64e18bd5efc23019366c9 |
| Source note | uspto-grants-2012_01 |