Phosphate → Meropenem Trihydrate

Participants

Reaction Steps

The process described as above is used to manufacture proteceted meropenem in crystalline form with desirable yield in about 90-95% and with a purity above 99%. Furthermore, protected meropenem is treated with palladium on charcoal (Pd/C) in a mixture of tetrahydrofuran and carbonate water or phosphate buffer or morpholine buffer of pH-7 so as to retain reaction mass pH 6.5 to 6.9 at temperature of 30-35° C. for 2- 3 hours to achieve a maximum yield. After completion of the reaction, the reaction mass is degasified and charcoalised to form a clear aqueous layer which is further reduced by distillation and finally acetone is added at a maintained temperature of 0-5° C. for 3 hours to get crystalline meropenem trihydrate in pure form.

Provenance & Evidence