1-(4'-Hydroxy-n-butyl)-1-cyclohexanol → 1-(4'-Formyl-n-butyl)-1-cyclohexanol

HRID 420881노트

반응식

HRID 420881 반응식
OCCCC[C:6]1([OH:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1.[Cr](Cl)([O-])(=O)=[O:14].[NH+]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(Cl)Cl>[CH:19]([CH2:20][CH2:21][CH2:22][CH2:23][C:6]1([OH:12])[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)=[O:14]

참가 물질

4

반응물 2

HCID 156207691-(4'-Hydroxy-n-butyl)-1-cyclohexanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 575744641-(4'-Formyl-n-butyl)-1-cyclohexanol수율 60%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 8 (10 gm, 6.33 mmol) in methylene chloride (25 ml) was added pyridinium chlorochromate (1.64 gm, 7.6 mmol) and the mixture was stirred at ambient temperature for 3 hours. The reaction mixture was passed through a silica column and eluted by methylene chloride to afford a pure hydroxy-aldehyde, 9 (0.7 gms).

후처리

  1. washeluted by methylene chloride

출처 및 근거

ORD 기록
ord-91b6069494a641c39a2f4f4424b247ca
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08097728B2

반응 노트

불러오는 중…