Hydrochloric Acid → HCID 66657612, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(4-chlorophenyl)-2-ethoxycarbonylmethyl-5-(4-trifluoromethylphenoxy)indole-3-carboxylic acid ethyl ester (140 mg, 0.25 mmol, see step (c) Example 2), NaOH (aq, 2M, 2 mL) and dioxane (2 mL) were heated at 120° C. for 4.5 h, cooled, diluted with H2O, acidified to pH 2 with HCl (aq, 1 M) and extracted with EtOAc. The combined extracts were washed with brine, dried (Na2SO4) and concentrated. The residue was treated with CH2Cl2 (2 mL) to give the title compound as a white solid which was recrystallised from CH2Cl2/EtOH (9:1). Yield 45 mg (37%), mp 974-276° C.

Provenance & Evidence