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HRID42092

反应详情

EQUATION

反应方程式

HRID 42092 的结构方程式

REACTANTS

反应物

2
结构：C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)CCC(=O)CC12
HCID67536381

未命名化合物

结构：C[C@]12CCCCC1/C(=N/O)C[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC13OCCOC12OCCO3
HCID178421204

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CCC(=O)CC1/C(=N/O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID87653583

未命名化合物

收率 70%

PROCEDURE

实验过程

The title compound II-ah was prepared in 70% yield from 3,3:17,17-bis(ethylendioxy)-6-(E)-hydroxyiminoandrostane by the procedure described above for the preparation of 6-methyleneandrostane-3,17-dione (II-ac, Prepn. 13). The combined organic extracts were washed with H2O, dried and evaporated to dryness. The residue was purified by flash chromatography (SiO2, n-hexane/acetone 70/30). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS): δ 10.61 (1H, s), 3.29 (1H, dd), 2.61-1.03 (19H, m), 0.88 (3H, s), 0.79 (3H, s).

WORKUP

后处理

  1. washThe combined organic extracts were washed with H2O
  2. customdried
  3. customevaporated to dryness
  4. customThe residue was purified by flash chromatography (SiO2, n-hexane/acetone 70/30)