4-(Trifluoromethyl)phenylboronic acid → HCID 66657676, compound

HRID 420921Notes

Reaction equation

HRID 420921 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([CH2:29][CH3:30])[C:21]4[C:26]([C:27]=3[CH:28]=2)=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:7]=1[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])=[O:5])[CH3:2].[F:37][C:38]([F:49])([F:48])[C:39]1[CH:44]=[CH:43][C:42](B(O)O)=[CH:41][CH:40]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:42]3[CH:43]=[CH:44][C:39]([C:38]([F:49])([F:48])[F:37])=[CH:40][CH:41]=3)[CH:13]=2)[N:8]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([CH2:29][CH3:30])[C:21]4[C:26]([C:27]=3[CH:28]=2)=[CH:25][CH:24]=[CH:23][CH:22]=4)[C:7]=1[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 66657711HCID 66657711, compound

Product 1

HCID 66657676HCID 66657676, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-1-(9-ethylcarbazol-3-yl)-5-hydroxyindole-3-carboxylic acid ethyl ester (170 mg, 0.35 mmol, see step (b) Example 14) and 4-trifluoromethylphenylboronic acid (100 mg, 0.53 mmol. Yield 130 mg (60%).

Sources & evidence

ORD record
ord-ceca3b8fd25a40b58c84dce8bd1b39ec
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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