Dimethylformamide → HCID 66657613, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-trifluoromethoxyphenyl)indole-3-carboxylic acid ethyl ester (100 mg, 0.22 mmol; see step (b) Example 9), 4,7-dichloroquinoline (66 mg, 0.33 mmol), K2CO3 (60 mg, 0.43 mmol) and DMF (2 mL) was stirred at 100-110° C. for 3 h, cooled, diluted with H2O (20 mL) and extracted with Et2O (30 mL). The extract was washed with H2O, dried (Na2SO4, concentrated and purified by chromatography to give the title compound. Yield 48 mg (36%).

Provenance & Evidence