4-Isopropoxybenzeneboronic acid → HCID 66657548, compound

HRID 420943Notes

Reaction equation

HRID 420943 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[C:7]=1[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:5])[CH3:2].[CH:30]([O:33][C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1)([CH3:32])[CH3:31]>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:37]3[CH:38]=[CH:39][C:34]([O:33][CH:30]([CH3:32])[CH3:31])=[CH:35][CH:36]=3)[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=2)[C:7]=1[CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 36987264-Isopropoxybenzeneboronic acidHCID 66657618HCID 66657618, compound

Product 1

HCID 66657548HCID 66657548, compound

Procedure

The sub-title compound was prepared in accordance with step (a) Example 24 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-methoxyphenyl)indole-3-carboxylic acid ethyl ester (153 mg, 0.40 mmol and 4-isopropoxyphenylboronic acid (108 mg, 0.60 mmol). Yield 111 mg, 52%.

Sources & evidence

ORD record
ord-552e8070bc6f4187bb60cf4f7a5baffb
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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