HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-N,N-dimethylnicotinamide → 1-(4-Diethylaminophenyl)-5-(5-dimethylcarbamoylpyridin-2-yloxy)-2-ethoxycarbonylmethylindole-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-N,N-dimethylnicotinamide | HCID 12364231 | — |
| Reactant | 1-(4-Diethylaminophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester | HCID 66657627 | — |
| Product | 1-(4-Diethylaminophenyl)-5-(5-dimethylcarbamoylpyridin-2-yloxy)-2-ethoxycarbonylmethylindole-3-carboxylic acid ethyl ester | HCID 66657693 | — |
Reaction Steps
The title compound was prepared in accordance with step (c) Example 38 from 1-(4-diethylaminophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester (120 mg, 0.28 mmol, see step (b) Example 1) and 6-chloro-N,N-dimethyl-nicotinamide (78 mg, 0.42 mmol). Yield 79 mg (48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097623B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-3c21d2aa3d0740b1a4584c42a014f36a |
| Source note | uspto-grants-2012_01 |