2-Chloro-5-nitropyridine → HCID 66658109, compound

HRID 420949Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15]C3C=CC(C(F)(F)F)=CC=3)[CH:13]=2)[N:8]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:28][CH:27]=2)[C:7]=1CC(O)=O)=[O:5])C.Cl[C:41]1[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][N:42]=1>>[CH3:1][O:3][C:4]([C:7]1[N:8]([C:26]2[CH:31]=[CH:30][C:29]([O:32][CH:33]([CH3:35])[CH3:34])=[CH:28][CH:27]=2)[C:9]2[C:14]([C:6]=1[C:4]([O:3][CH3:1])=[O:5])=[CH:13][C:12]([O:15][C:41]1[CH:46]=[CH:45][C:44]([N+:47]([O-:49])=[O:48])=[CH:43][N:42]=1)=[CH:11][CH:10]=2)=[O:5]

Participants

Reactant 2

HCID 783082-Chloro-5-nitropyridine

HCID 66658214HCID 66658214, compound

Product 1

HCID 66658109HCID 66658109, compound

Procedure

The title compound was prepared in accordance with step (c) Example 38 from 5-hydroxy-1-(4-isopropoxyphenyl)indole-2,3-dicarboxylic acid dimethyl ester (150 mg, 0.39 mmol, see (b) Example 12) and 2-chloro-5-nitropyridin (75 mg, 0.47 mmol). Yield 169 mg (86%).

Sources & evidence

ORD record: ord-e2f6157aa23a4f28abad187d2721d4eb
Source dataset: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08097623B2

Reaction notes

Loading…