4-tert-Butylphenylboronic acid → HCID 66658093, compound

HRID 420952Notes

Reaction equation

HRID 420952 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH:26]([CH3:28])[CH3:27])=[CH:21][CH:20]=2)[C:7]2[C:12]([C:13]=1[C:14]([O:16][CH3:17])=[O:15])=[CH:11][C:10]([OH:18])=[CH:9][CH:8]=2)=[O:4].[C:29]([C:33]1[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=1)([CH3:32])([CH3:31])[CH3:30]>>[CH3:1][O:2][C:3]([C:5]1[N:6]([C:19]2[CH:20]=[CH:21][C:22]([O:25][CH:26]([CH3:28])[CH3:27])=[CH:23][CH:24]=2)[C:7]2[C:12]([C:13]=1[C:14]([O:16][CH3:17])=[O:15])=[CH:11][C:10]([O:18][C:36]1[CH:37]=[CH:38][C:33]([C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:34][CH:35]=1)=[CH:9][CH:8]=2)=[O:4]

Participants

3

Reactant 2

HCID 27343204-tert-Butylphenylboronic acidHCID 57419904HCID 57419904, compound

Product 1

HCID 66658093HCID 66658093, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 5-hydroxy-1-(4-isopropoxyphenyl)indole-2,3-dicarboxylic acid dimethyl ester (250 mg, 0.65 mmol, see step (a) Example 19) and 4-tert-butylphenylboronic acid (175 mg, 0.98 mmol). Yield 240 mg (72%).

Sources & evidence

ORD record
ord-a3e5dcdaa4434549b6240df5306cd5b3
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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