(3-Chlorophenyl)boronic acid → HCID 66657694, compound

HRID 420955Notes

Reaction equation

HRID 420955 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH:26]([CH3:28])[CH3:27])=[CH:21][CH:20]=2)[C:7]2[C:12]([C:13]=1[C:14]([O:16][CH3:17])=[O:15])=[CH:11][C:10]([OH:18])=[CH:9][CH:8]=2)=[O:4].[Cl:29][C:30]1[CH:31]=[C:32](B(O)O)[CH:33]=[CH:34][CH:35]=1>>[CH3:1][O:2][C:3]([C:5]1[N:6]([C:19]2[CH:20]=[CH:21][C:22]([O:25][CH:26]([CH3:28])[CH3:27])=[CH:23][CH:24]=2)[C:7]2[C:12]([C:13]=1[C:14]([O:16][CH3:17])=[O:15])=[CH:11][C:10]([O:18][C:34]1[CH:33]=[CH:32][CH:31]=[C:30]([Cl:29])[CH:35]=1)=[CH:9][CH:8]=2)=[O:4]

Participants

3

Reactant 2

HCID 2734323(3-Chlorophenyl)boronic acidHCID 57419904HCID 57419904, compound

Product 1

HCID 66657694HCID 66657694, compound

Procedure

The sub-title compound was prepared in accordance with step (a) Example 18 from 5-hydroxyindole-1-(4-isopropoxyphenyl)-2,3-dicarboxylic acid dimethyl ester (150 mg-0.39 mmol, see step (a) Example 19) and 3-chlorophenylboronic acid (120 mg, 0.78 mmol). Yield 93 mg (49%).

Sources & evidence

ORD record
ord-4accb34dae57471fb85fc0d618767e33
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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