4-Chlorophenylboronic acid → HCID 66657669, compound

HRID 420956Notes

Reaction equation

HRID 420956 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[CH:18][CH:17]=2)[C:7]=1[CH2:27][C:28]([O:30]CC)=[O:29])=[O:5])[CH3:2].[Cl:33][C:34]1[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=1>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:37]3[CH:38]=[CH:39][C:34]([Cl:33])=[CH:35][CH:36]=3)[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]([F:24])([F:25])[F:26])=[CH:18][CH:17]=2)[C:7]=1[CH2:27][C:28]([OH:30])=[O:29])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 66657846HCID 66657846, compound

Product 1

HCID 66657669HCID 66657669, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-trifluoromethoxyphenyl)indole-3-carboxylic acid ethyl ester (150 mg, 0.39 mmol, see step (b) Example 9) and 4-chlorophenylboronic acid (110 mg, 0.68 mmol). Yield 140 mg (74%).

Sources & evidence

ORD record
ord-09813ce9fc614e93b75be13b4a56dfc3
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

Loading…