3,4-Dichlorobenzeneboronic acid → HCID 66657815, compound

HRID 420962Notes

Reaction equation

HRID 420962 reaction equation
C([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([CH:22]([CH3:24])[CH3:23])=[CH:18][CH:17]=2)[C:7]=1[CH2:25][C:26]([O:28]CC)=[O:27])=[O:5])C.[Cl:31][C:32]1[CH:33]=[C:34](B(O)O)[CH:35]=[CH:36][C:37]=1[Cl:38]>>[C:4]([CH2:6][C:7]1[N:8]([C:16]2[CH:21]=[CH:20][C:19]([CH:22]([CH3:23])[CH3:24])=[CH:18][CH:17]=2)[C:9]2[C:10]([C:25]=1[C:26]([OH:28])=[O:27])=[CH:11][C:12]([O:15][C:35]1[CH:34]=[CH:33][C:32]([Cl:31])=[C:37]([Cl:38])[CH:36]=1)=[CH:13][CH:14]=2)([OH:3])=[O:5]

Participants

3

Reactant 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 66657684HCID 66657684, compound

Product 1

HCID 66657815HCID 66657815, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-isopropylphenyl)indole-3-carboxylic acid ethyl ester (150 mg, 0.37 mmol, see step (b) Example 10) and 3,4-dichlorophenylboronic acid (140 mg, 0.74 mmol). Yield 110 mg (55%).

Sources & evidence

ORD record
ord-4f40977da5d44f38a1a6f536ee3b422d
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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