3-(Trifluoromethyl)phenylboronic acid → HCID 66657565, compound

HRID 420963Notes

Reaction equation

HRID 420963 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([CH:22]([CH3:24])[CH3:23])=[CH:18][CH:17]=2)[C:7]=1[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:5])[CH3:2].[F:31][C:32]([F:43])([F:42])[C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[CH:37][CH:38]=1>N1C=CC=CC=1>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:37]3[CH:36]=[CH:35][CH:34]=[C:33]([C:32]([F:43])([F:42])[F:31])[CH:38]=3)[CH:13]=2)[N:8]([C:16]2[CH:17]=[CH:18][C:19]([CH:22]([CH3:24])[CH3:23])=[CH:20][CH:21]=2)[C:7]=1[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 66657684HCID 66657684, compound

Product 1

HCID 66657565HCID 66657565, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-isopropylphenyl)indole-3-carboxylic acid ethyl ester (150 mg, 0.37 mmol, see step (b) Example 10) and 3-trifluoromethylphenylboronic acid (140 mg, 0.74 mmol), pyridine. Yield 130 mg (65%).

Sources & evidence

ORD record
ord-77f946c7167e48049596f331bf013841
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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