4-Isopropoxybenzeneboronic acid → HCID 66657546, compound

HRID 420964Notes

Reaction equation

HRID 420964 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][C:19]([CH:22]([CH3:24])[CH3:23])=[CH:18][CH:17]=2)[C:7]=1[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:5])[CH3:2].[CH:31]([O:34][C:35]1[CH:40]=[CH:39][C:38](B(O)O)=[CH:37][CH:36]=1)([CH3:33])[CH3:32]>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:38]3[CH:39]=[CH:40][C:35]([O:34][CH:31]([CH3:33])[CH3:32])=[CH:36][CH:37]=3)[CH:13]=2)[N:8]([C:16]2[CH:17]=[CH:18][C:19]([CH:22]([CH3:24])[CH3:23])=[CH:20][CH:21]=2)[C:7]=1[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 36987264-Isopropoxybenzeneboronic acidHCID 66657684HCID 66657684, compound

Product 1

HCID 66657546HCID 66657546, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 2-ethoxycarbonylmethyl-5-hydroxy-1-(4-isopropylphenyl)indole-3-carboxylic acid ethyl ester (150 mg, 0.37 mmol, see step (b) Example 10) and 4-isopropoxyphenylboronic acid (130 mg, 0.74 mmol). Yield 100 mg (50%).

Sources & evidence

ORD record
ord-c7dbc9c2d45e480db28daeebcb34ac11
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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