4-Chlorophenylboronic acid → HCID 66657597, compound

HRID 420966Notes

Reaction equation

HRID 420966 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([OH:14])[CH:12]=2)[N:7]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH:22]([CH3:24])[CH3:23])=[CH:17][CH:16]=2)[C:6]=1[C:25]1[CH:30]=[CH:29][C:28]([C:31]([O:33][CH3:34])=[O:32])=[CH:27][CH:26]=1)=[O:4].[Cl:35][C:36]1[CH:41]=[CH:40][C:39](B(O)O)=[CH:38][CH:37]=1>>[CH3:1][O:2][C:3]([C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][C:39]3[CH:40]=[CH:41][C:36]([Cl:35])=[CH:37][CH:38]=3)[CH:12]=2)[N:7]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH:22]([CH3:24])[CH3:23])=[CH:19][CH:20]=2)[C:6]=1[C:25]1[CH:26]=[CH:27][C:28]([C:31]([O:33][CH3:34])=[O:32])=[CH:29][CH:30]=1)=[O:4]

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 66657622HCID 66657622, compound

Product 1

HCID 66657597HCID 66657597, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 5-hydroxy-1-(4-isopropoxyphenyl)-2-(4-methoxycarbonylphenyl)indole-3-carboxylic acid methyl ester (150 mg, 0.32 mmol, see step (b) Example 43) and 4-chlorophenylboronic acid (100 mg, 0.64 mmol). Yield 97 mg (54%).

Sources & evidence

ORD record
ord-95b7f401546240ed80fc636c145cdc40
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

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