Ethanol → HCID 66657649, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-carbamoylpyridin-2-yl-oxy)-2-ethoxycarbonylmethyl-1-(4-trifluoromethoxy-phenyl)indole-3-carboxylic acid ethyl ester (86 mg, 0.15 mmol, see step (a) above), NaOH (aq, 1M, 0.45 mL), EtOH (1 mL) and H2O (1 mL) was stirred at 55° C. for 3 h, cooled, filtered through Celite® and acidified to pH 4 with HCl (aq, 2M). The solid was filtered off, washed with H2O and purified by chromatography and recrystallisation from EtOAc. Yield 36 mg (46%), mp 128-130° C.

Provenance & Evidence