Sodium Hydroxide → HCID 66657747, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(3-carbamoylpyridin-2-yloxy)-2-ethoxycarbonylmethyl-1-(4-isopropoxyphenyl)indole-3-carboxylic acid ethyl ester (63 mg, 0.12 mmol, see step (a) Example 65), NaOH (aq, 2M, 0.35 mL) and EtOH (2 mL) was stirred at 90° C. for 8 h, concentrated, diluted with MeOH and filtered through Celite®. EtOAc was added to the filtrate which was cooled for 4 h at 5° C. The solid was collected and dissolved in H2O. The mixture was acidified to pH 4 with HCl (aq, 2 M). The solid was filtered off and dried for 4 h at 60° C. to give the title compound. Yield 34 mg (60%), mp 212-214° C. after recrystallisation from EtOAc/MeOH.

Provenance & Evidence