Potassium Carbonate → HCID 66657452, compound

Participants

Reaction Steps

A mixture 2-ethoxycarbonylmethyl-1-(4-isopropylphenyl)-5-trifluoromethane-sulfonyloxyindole-3-carboxylic acid ethyl ester (133 mg, 0.25 mmol, see step (a) above), 4-trifluoromethylphenylboronic acid (142 mg, 0.75 mmol), K2CO3 (276 mg, 2 mmol), tetrakis(triphenylphosphine)palladium(0) (78 mg, 0.067 mmol) and anhydrous dioxane (10 mL) was stirred at 90° C. for 4 h. The mixture was diluted with EtOAc (30 mL), washed with saturated NaHCO3 (aq, sat) dried (Na2SO4), concentrated and purified by chromatography to give the sub-title compound. Yield 102 mg (76%).

Provenance & Evidence