4-Isopropoxybenzeneboronic acid → HCID 66657731, compound

HRID 420987Notes

Reaction equation

HRID 420987 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=2)[C:7]=1[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:5])[CH3:2].[CH:29]([O:32][C:33]1[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=1)([CH3:31])[CH3:30]>>[CH2:1]([O:3][C:4]([C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][C:36]3[CH:37]=[CH:38][C:33]([O:32][CH:29]([CH3:31])[CH3:30])=[CH:34][CH:35]=3)[CH:13]=2)[N:8]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=2)[C:7]=1[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 36987264-Isopropoxybenzeneboronic acidHCID 66657603HCID 66657603, compound

Product 1

HCID 66657731HCID 66657731, compound

Procedure

The sub-title compound was prepared in accordance with step (c) Example 1 from 1-(3-chlorophenyl)-2-ethoxycarbonylmethyl-5-hydroxyindole-3-carboxylic acid ethyl ester (135 mg, 0.34 mmol, see step (b) Example 8) and 4-isopropoxyphenylboronic acid (91 mg, 0.50 mmol). Yield 70 mg (39%).

Sources & evidence

ORD record
ord-0810efcf9dfa4b1881e9597043b69f5f
Source dataset
uspto-grants-2012_01
Patent number
US08097623B2

Reaction notes

Loading…