Hydrochloric Acid → HCID 66658227, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(3-chlorophenyl)-2-ethoxycarbonylmethyl-5-(4-isopropoxyphenoxy)indole-3-carboxylic acid ethyl ester (65 mg, 0.12 mmol, see step (a) above), NaOH (aq, 1 M, 15 mL), and EtOH (20 mL) was heated at 50° C. for 48 h and stirred at rt overnight and acidified to pH 4 with HCl (aq, 1 M) and extracted with CH2Cl2. The organic layer was washed with H2O and brine, dried (Na2SO4), concentrated and purified by chromatography. Yield 45 mg (78%), mp 188-190° C.

Provenance & Evidence