Tetrahydrofuran → HCID 66657790, compound

Participants

Reaction Steps

3-(2-Acetylamino-1-(4-cyclopentyloxyphenyl)-2-ethoxycarbonylvinyl)-5-(4-trifluoromethylphenyl)indole-2-carboxylic acid ethyl ester ('370 mg-, 0.58 mmol; see step (b) above) in MeOH (15 mL) and THF (115 mL) was hydrogenated (rt, 7 bar) over Pd—C (10%, 300 mg) for 6.5 h. The mixture was filtered through Celite® and concentrated to give sub-title compound. Yield 378 mg (1100%)

Provenance & Evidence