HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 420994Generated: October 31, 2026
Hydrochloric Acid → 5-(4-tert-Butylphenyl)-3-[(ethoxycarbonylmethylmethylamino)methyl]-1-(4-isopropoxyphenyl)indole-2-carboxylic acid
https://huagongshe.com/reaction/420994
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-(4-tert-Butylphenyl)-3-[(ethoxycarbonylmethylmethylamino)methyl]-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester | HCID 66657716 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(4-tert-Butylphenyl)-3-[(ethoxycarbonylmethylmethylamino)methyl]-1-(4-isopropoxyphenyl)indole-2-carboxylic acid | HCID 66657582 | — |
Reaction Steps
A mixture of 5-(4-tert-butylphenyl)-3-[(ethoxycarbonylmethylmethylamino)methyl]-1-(4-isopropoxyphenyl)indole-2-carboxylic acid ethyl ester (198 mg, 0.36 mmol, see step (d)), NaOH (aq, 1 M, 2 mL) and dioxane (3 mL) was heated at 120° C. for 30 min, cooled, acidified with HCl (aq, 1 M) to pH 5 and extracted with EtOAc. The combined extracts were washed with H2O and brine, dried (Na2SO4), concentrated and purified by chromatography to afford the sub-title compound. Yield 184 mg (98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08097623B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-95d86dd038224dfd89b3f2d980642fbf |
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| Source note | uspto-grants-2012_01 |
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