Water → HCID 66657620, compound

Participants

Reaction Steps

(Carbethoxymethylene)triphenylphosphorane (330 mg, 0.95 mmol) was added to a suspension of 3-formyl-1-(4-isopropoxyphenyl)-5-(5-trifluoromethylpyridin-2-yl)indole-2-carboxylic acid ethyl ester (427 mg, 0.95 mmol; see step (b) above) in DMF (15 mL) and the mixture was stirred at rt for 3 h. Another portion of (carbethoxymethylene)triphenylphosphorane (165 mg, 0.47 mmol) was added and the stirring continued for 12 h. The mixture was poured into H2O and extracted with EtOAc. The combined extracts were washed with H2O, brine, dried (Na2SO4), concentrated and purified by chromatography to give the sub-title compound. Yield 386 mg (80%).

Provenance & Evidence