Hydrochloric Acid → HCID 66657589, compound

Participants

Reaction Steps

A mixture of 2-ethoxycarbonylmethyl-5-(3-chlorophenoxy)-1-(4-isopropoxyphenyl)indole-3-carboxylic acid ethyl ester (0.10 g, 0.19 mmol); see step (b) above), NaOH (0.10 g, 2.50 mmol), H2O (2.5 mL) and EtOH (2.5 mL) was heated at reflux for 2 h, cooled and acidified with HCl (aq, conc). The solid was collected and dried to afford the title compound. Yield 0.06 g (66%).

Provenance & Evidence