HuagongsheHuagongshe Chemistry Print Report · For research reference only
17,17-Bis(ethylendioxy)-5alpha-hydroxyandrostan-6-one → HCID 154041431, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 17,17-Bis(ethylendioxy)-5alpha-hydroxyandrostan-6-one | HCID 86635579 | — |
| Reactant | (6E,8R,9S,10R,13S,14S)-6-hydroxyimino-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione | HCID 87653583 | — |
| Product | HCID 154041431 | HCID 154041431 | 85% |
Reaction Steps
17,17-Bis(ethylendioxy)-5α-hydroxy-6-(E)-hydroxyimino-androstane was prepared in 85% yield from 3,3:17,17-bis(ethylendioxy)-5α-hydroxyandrostan-6-one (Prepn. 26) by the procedure described above for the preparation of 6-(E)-hydroxyiminoandrostane-3,17-dione (II-ah, Prepn. 18). The crude was purified by flash chromatography (SiO2, cyclohexane/acetone/CH2Cl2 70/15/15). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS: δ 10.45 (1H, s), 4.33 (1H, s), 3.96-3.69 (8H, m), 2.96 (1H, dd), 2.02-1.08 (18H, m), 0.74 (3H, s), 0.71 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08536160B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-b450267566264f96bf1fd740441dea73 |
| Source note | uspto-grants-2013_09 |