Benzenamine, 3,5-bis(trifluoromethyl)- → N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-(trifluoromethyl)benzamide

HRID 421057Notes

Reaction equation

HRID 421057 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19]([CH:21]=[C:22]([C:24]([F:27])([F:26])[F:25])[CH:23]=1)[NH2:20]>>[F:15][C:16]([F:28])([F:29])[C:17]1[CH:18]=[C:19]([NH:20][C:4](=[O:6])[C:3]2[CH:7]=[C:8]([C:11]([F:14])([F:13])[F:12])[CH:9]=[CH:10][C:2]=2[OH:1])[CH:21]=[C:22]([C:24]([F:25])([F:27])[F:26])[CH:23]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 111172032-hydroxy-5-(trifluoromethyl)benzoic Acid

Product 1

HCID 11212219N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-(trifluoromethyl)benzamide

Procedure

Using 2-hydroxy-5-(trifluoromethyl)benzoic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound. (2-Hydroxy-5-(trifluoromethyl)benzoic acid: refer to Chem. Pharm. Bull., 1996, 44, 734.)

Sources & evidence

ORD record
ord-4413d956420b4690953c12ae833140e5
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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