Thiophene-3-boronic acid → HCID 10252154, compound

HRID 421061Notes

Reaction equation

HRID 421061 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([NH:13][C:14](=[O:23])[C:15]2[CH:20]=[C:19](I)[CH:18]=[CH:17][C:16]=2[OH:22])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[S:26]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27]1>>[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([NH:13][C:14](=[O:23])[C:15]2[CH:20]=[C:19]([C:28]3[CH:29]=[CH:30][S:26][CH:27]=3)[CH:18]=[CH:17][C:16]=2[OH:22])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 11190699N-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-5-iodo-benzamide

Product 1

HCID 10252154HCID 10252154, compoundYield 38.7%

Procedure

Using N-[3,5-bis(trifluoromethyl)phenyl] 2-hydroxy-5-iodobenzamide and 3-thipheneboronic acid as the raw materials, the same operation as the example 69 gave the title compound.

Sources & evidence

ORD record
ord-da632ecf5b0f444b92974989763af45f
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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