Benzenamine, 3,5-bis(trifluoromethyl)- → N-[3,5-bis(trifluoromethyl)phenyl]-2-methoxy-5-sulfamoylbenzamide

HRID 421079Notes

Reaction equation

HRID 421079 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([S:12](=[O:15])(=[O:14])[NH2:13])=[CH:8][C:4]=1[C:5]([OH:7])=O.[F:16][C:17]([F:30])([F:29])[C:18]1[CH:19]=[C:20]([CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:24]=1)[NH2:21]>>[F:16][C:17]([F:29])([F:30])[C:18]1[CH:19]=[C:20]([NH:21][C:5](=[O:7])[C:4]2[CH:8]=[C:9]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:10]=[CH:11][C:3]=2[O:2][CH3:1])[CH:22]=[C:23]([C:25]([F:26])([F:28])[F:27])[CH:24]=1

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 896012-Methoxy-5-sulfamoylbenzoic acid

Product 1

HCID 29204801N-[3,5-bis(trifluoromethyl)phenyl]-2-methoxy-5-sulfamoylbenzamideYield 24.2%

Procedure

Using 2-methoxy-5-sulfamoylbenzoic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 24 gave the title compound.

Sources & evidence

ORD record
ord-041f3beecebc4e8f84595c664dd85bdb
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

Loading…