Benzenamine, 3,5-bis(trifluoromethyl)- → 4-Acetylamino-N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-methoxybenzamide

HRID 421086Notes

Reaction equation

HRID 421086 reaction equation
[C:1]([NH:4][C:5]1[C:13]([Cl:14])=[CH:12][C:8]([C:9]([OH:11])=O)=[C:7]([O:15][CH3:16])[CH:6]=1)(=[O:3])[CH3:2].[F:17][C:18]([F:31])([F:30])[C:19]1[CH:20]=[C:21]([CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1)[NH2:22]>>[C:1]([NH:4][C:5]1[C:13]([Cl:14])=[CH:12][C:8]([C:9]([NH:22][C:21]2[CH:23]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:25]=[C:19]([C:18]([F:17])([F:30])[F:31])[CH:20]=2)=[O:11])=[C:7]([O:15][CH3:16])[CH:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-HCID 109884964-Acetamido-5-chloro-2-methoxybenzoic acid

Product 1

HCID 178602074-Acetylamino-N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-methoxybenzamideYield 23.8%

Procedure

Using 4-acetylamino-5-chloro-2-methoxybenzoic acid and 3,5-bis(trifluoromethyl)aniline as the raw materials, the same operation as the example 24 gave the title compound.

Sources & evidence

ORD record
ord-0fe1577beffb4f27b26d5e6e0164aa62
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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