Acetyl chloride → 2-Acetoxy-N-[2,5-bis(trifluoromethyl)phenyl]-5-chlorobenzamide

HRID 421091Notes

Reaction equation

HRID 421091 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[NH:13][C:14](=[O:23])[C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[CH:17][C:16]=1[OH:22].[C:26](Cl)(=[O:28])[CH3:27]>>[C:26]([O:22][C:16]1[CH:17]=[CH:18][C:19]([Cl:21])=[CH:20][C:15]=1[C:14]([NH:13][C:4]1[CH:5]=[C:6]([C:9]([F:10])([F:11])[F:12])[CH:7]=[CH:8][C:3]=1[C:2]([F:1])([F:24])[F:25])=[O:23])(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 230703595-Chloro-2-hydroxy-N-[2,5-bis(trifluoromethyl)phenyl]benzamide

Product 1

HCID 178601442-Acetoxy-N-[2,5-bis(trifluoromethyl)phenyl]-5-chlorobenzamideYield 6.6%

Procedure

Using N-[2,5-bis(trifluoromethyl)phenyl] 5-chloro-2-hydroxybenzamide and acetyl chloride as the raw materials, the same operation as the example 96 gave the title compound.

Sources & evidence

ORD record
ord-36b3cbb2dbc04d2482dcdece941b0ba1
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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