2-(Trifluoromethyl)aniline → HCID 23281998, compound

HRID 421092Notes

Reaction equation

HRID 421092 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]([F:22])([F:21])[C:14]1[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=1[NH2:16]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:16][C:15]1[CH:17]=[CH:18][CH:19]=[CH:20][C:14]=1[C:13]([F:12])([F:21])[F:22])=[O:9]

Participants

3

Reactant 2

HCID 69222-(Trifluoromethyl)anilineHCID 94475-Chlorosalicylic Acid

Product 1

HCID 23281998HCID 23281998, compoundYield 58%

Procedure

Using 5-chlorosalicylic acid and 2-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-e7894245528c4566a519ef4f1c7de55a
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

Loading…