5-Chlorosalicylic Acid → HCID 17860118, compound

HRID 421095Notes

Reaction equation

HRID 421095 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:17][C:16]1[CH:18]=[CH:19][C:13]([F:12])=[C:14]([C:20]([F:23])([F:21])[F:22])[CH:15]=1)=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 753774-Fluoro-3-(trifluoromethyl)aniline

Product 1

HCID 17860118HCID 17860118, compoundYield 72.1%

Procedure

Using 5-chlorosalicylic acid and 4-fluoro-3-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-b0830e6ba5cf4f46bfad366cecd8ed1f
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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