5-Chlorosalicylic Acid → 5-Chloro-2-hydroxy-N-[4-methyl-3-(trifluoromethyl)phenyl]benzamide

HRID 421105Notes

Reaction equation

HRID 421105 reaction equation
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH3:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:17][C:16]1[CH:18]=[CH:19][C:13]([CH3:12])=[C:14]([C:20]([F:21])([F:22])[F:23])[CH:15]=1)=[O:9]

Participants

3

Reactant 2

HCID 94475-Chlorosalicylic AcidHCID 27377154-Methyl-3-(trifluoromethyl)aniline

Product 1

HCID 178602475-Chloro-2-hydroxy-N-[4-methyl-3-(trifluoromethyl)phenyl]benzamideYield 80.2%

Procedure

Using 5-chlorosalicylic acid and 4-methyl-3-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-ab337c471148475ca53a5f5097ec6539
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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