HCID 67536381, compound → (7E,8R,9S,10S,13S,14S)-7-hydroxyimino-10,13-dimethyl-1,2,4,5,6,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione

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Reaction Steps

The title compound II-at was prepared in 50% yield from 3,3:17,17-bis(ethylendioxy)-7-(E)-hydroxyiminoandrostane by the procedure described above for the preparation of 6-methyleneandrostane-3,17-dione (II-ac, Prepn. 13). The combined organic extracts were washed with H2O, dried over Na2SO4 and evaporated to dryness. The crude product was purified by flash chromatography (SiO2, n-hexane/EtOAc 6/4). 1H-NMR (300 MHz, DMSO-d6, ppm from TMS: δ 10.37 (1H, s), 2.99 (1H, m), 2.58-0.67 (19H, m), 1.12 (3H, s), 0.82 (3H, s).

Provenance & Evidence