5-Methylsalicylic acid → HCID 17860273, compound

HRID 421120Notes

Reaction equation

HRID 421120 reaction equation
[CH3:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][C:15]=1[C:21]([F:24])([F:23])[F:22]>>[OH:11][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:10][C:6]=1[C:7]([NH:18][C:17]1[CH:19]=[CH:20][C:14]([O:13][CH3:12])=[C:15]([C:21]([F:22])([F:23])[F:24])[CH:16]=1)=[O:9]

Participants

3

Reactant 2

HCID 69735-Methylsalicylic acidHCID 6007055-Amino-2-methoxybenzotrifluoride

Product 1

HCID 17860273HCID 17860273, compoundYield 65.1%

Procedure

Using 5-methylsalicylic acid and 4-methoxy-3-(trifluoromethyl)aniline as the raw materials, the same operation as the example 16 gave the title compound.

Sources & evidence

ORD record
ord-597256c77e064c8db1a5dc513432f478
Source dataset
uspto-grants-2012_01
Patent number
US08097759B2

Reaction notes

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