HCID 59215904, compound → HCID 59215849, compound

Participants

Reaction Steps

To a solution of (7S,9aS)-7-(fluoromethyl)-8-(phenylmethyl)octahydropyrazino[2,1-c][1,4]oxazine (D128, 30 mg, 0.11 mmol) in AcOH (30 ml) was added Pd-black (12 mg, 0.11 mmol) and the reaction mixture was stirred under a H2 atmosphere (5 atm.) for 1.5 hrs. The reaction mixture was filtered on a SCX cartridge washing with methanol and then with 2M methanolic ammonia. The fractions eluted with ammonia were combined and evaporated to dryness. The crude was purified by chromatography (silica, CH2Cl2:MeOH1:0 to 8:2) to give the title compound (14.9 mg, y=78%).

Provenance & Evidence