HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide | HCID 16063951 | — |
| Product | 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride | HCID 16063996 | — |
Reaction Steps
HCl salt made according to method described in Example 41 starting from 2-[3,5-bis(trifluoromethyl)phenyl]-N-{6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-[2-(hydroxymethyl)phenyl]-3-pyridinyl}-N,2-dimethylpropanamide (E49, 10.2 mg) to afford a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08097618B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-c9754f6a28014fc9ac7a13b61422405e |
| Source note | uspto-grants-2012_01 |