3alpha-Acetylthio-6-methyleneandrostan-17-one → 3alpha-Mercapto-6-methyleneandrostan-17-one

Participants

Reaction Steps

To a solution of 3α-acetylthio-6-methyleneandrostan-17-one (210 mg) in MeOH (3 mL), 1N NaOH (0.6 mL) was added. After 1 h at room temperature 5% NaH2PO4 aqueous solution was added and the mixture extracted with Et2O (2×20 mL). The combined organic extracts were washed with brine, dried over Na2SO4 and evaporated to dryness to give the title compound (185 mg, 100%).

Provenance & Evidence