Methanesulfonic Acid → 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine methanesulfonate

Participants

Reaction Steps

To a solution of 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine (33.2 mg, 0.06 mmol) in methanol/dichloromethane solution (1/1, 1 ml) was added methanesulfonic acid (3.9 μl, 0.06 mmol) at room temperature, and the mixture was stirred for 3 hr. Then the solvent was removed in reduced pressure, and the resultant solid was dried to give 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine methanesulfonate (31.4 mg) as a yellow solid.

Provenance & Evidence