反应详情

温度

50 °C

To a suspension of 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine (48.7 mg, 0.09 mmol) in 10% aqueous ethanol solution (1 ml) was added 98% sulfuric acid (5.44 μL, 0.09 mmol) at room temperature, and the mixture was heated up to 50° C., then allowed to be cooled down to r.t., and stirred for 5 hr. The solid precipitated out was collected and dried to give 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine sulfate (48.9 mg) as a yellow solid.

1. temperatureto be cooled down to r.t.
2. customThe solid precipitated out
3. customwas collected
4. customdried