Hydroxybenzenesulfonic acid → 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine benzenesulfonate

Participants

Reaction Steps

To a suspension of 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine (53.8 mg, 0.1 mmol) in 10% aqueous ethanol solution (0.6 ml) was added benzenesulfonic acid mono hydrate (20.0 mg, 0.11 mmol) at 50° C., and the mixture was cooled down to room temperature, and was stirred for 5 hr. The solid precipitated out was collected and dried to give 5-{8-[(3S)-4-acetyl-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl}pyrimidin-2-amine benzenesulfonate (52.4 mg) as a yellow solid.

Provenance & Evidence