反应详情

1 N Hydrochloric acid-ethanol (105 ml, 105 mmol) and 5% palladium carbon (3 g) were added to an ethanol (250 ml) solution of the compound (15.5 g, 51 mmol) obtained in Step 4 above and contact reduction was performed for 15 hours in a hydrogen atmosphere. The catalyst was filtrated through celite, then the filtrate was concentrated under reduced pressure, an ethanol-diethyl ether mixed solvent was added to the resulting residue, and the precipitated solid was collected by filtration to give the title compound (10.3 g, 83%) as a colorless solid.

1. filtrationThe catalyst was filtrated through celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionan ethanol-diethyl ether mixed solvent was added to the resulting residue
4. filtrationthe precipitated solid was collected by filtration