4-Fluorobenzaldehyde → 1-[(4-Fluoro-benzylamino)-methyl]-cyclopropanecarboxylic acid methyl ester

Temperature

0 °C

(Trimethylsilyl)diazomethane (4.41 mL of a 1.0 M solution in diethyl ether, 8.82 mmol) was added over 5 min to a solution of racemic 1-(tert-butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (0.95 g, 4.41 mmol) in a 1:1 mixture of methanol/benzene (30 mL) at 0° C. The resulting yellow solution was stirred at 0° C. for 1 h, and then was concentrated in vacuo. The residue was dissolved in 1,4-dioxane (20 mL) at 25° C. and a 4.0 M solution of hydrochloric acid in 1,4-dioxane (20 mL) was subsequently added. After stirring at 25° C. for 5 h, the reaction mixture was concentrated in vacuo to afford a sticky oil. This material was dissolved in toluene (80 mL) and the solution was concentrated in vacuo (the process was then repeated). The resulting residue was dissolved in methanol (30 mL) at 25° C. and 4-fluorobenzaldehyde (0.473 mL, 4.41 mmol), sodium acetate (0.723 g, 8.81 mmol), powdered/activated 4 Å molecular sieves (1.87 g) and sodium cyanoborohydride (0.554 g, 8.82 mmol) were added sequentially. The mixture was stirred at 25° C. for 19 h, then was filtered through Celite. The Celite was washed with methanol (2×30 mL) and the combined filtrate and washings were concentrated in vacuo. The residue was partitioned between half-saturated aqueous sodium bicarbonate solution (150 mL) and ethyl acetate (2×150 mL). The combined organic layers were dried over sodium sulfate and were concentrated in vacuo. The residue was purified by flash column chromatography (Teledyne Isco RediSep column; 50-100% ethyl acetate in hexanes) to afford 1-[(4-fluoro-benzylamino)-methyl]-cyclopropanecarboxylic acid methyl ester (0.050 g, 0.211 mmol, 5%) as a pale yellow oil. 1H NMR (400 MHz, CDCl3) δ: 0.79-0.82 (2H, m), 1.26-1.28 (2H, m), 2.70 (2H, s), 3.66 (3H, s), 3.79 (2H, s), 6.97-7.01 (2H, m), 7.28-7.31 (2H, m).

1. concentrationwas concentrated in vacuo
2. dissolutionThe residue was dissolved in 1,4-dioxane (20 mL) at 25° C.
3. additiona 4.0 M solution of hydrochloric acid in 1,4-dioxane (20 mL) was subsequently added
4. stirringAfter stirring at 25° C. for 5 h
5. concentrationthe reaction mixture was concentrated in vacuo
6. customto afford a sticky oil
7. concentrationthe solution was concentrated in vacuo (the process
8. dissolutionThe resulting residue was dissolved in methanol (30 mL) at 25° C.
9. stirringThe mixture was stirred at 25° C. for 19 h
10. filtrationwas filtered through Celite
11. washThe Celite was washed with methanol (2×30 mL)
12. concentrationthe combined filtrate and washings were concentrated in vacuo
13. customThe residue was partitioned between half-saturated aqueous sodium bicarbonate solution (150 mL) and ethyl acetate (2×150 mL)
14. dry with materialThe combined organic layers were dried over sodium sulfate
15. concentrationwere concentrated in vacuo
16. customThe residue was purified by flash column chromatography (Teledyne Isco RediSep column; 50-100% ethyl acetate in hexanes)

ORD record

ord-c038b25295db4aa08f6b2fd22b6db9e4

Source dataset

uspto-grants-2012_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08097613B2