Potassium Hydroxide → Potassium 4-sulfamoylphenolate

HRID 42150Notes

Reaction equation

HRID 42150 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[K+:13]>C(O)C>[S:8]([C:5]1[CH:4]=[CH:3][C:2]([O-:1])=[CH:7][CH:6]=1)(=[O:9])(=[O:10])[NH2:11].[K+:13]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 74093p-Hydroxybenzenesulfonamide

Product 1

HCID 67083060Potassium 4-sulfamoylphenolate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4-hydroxybenzenesulfonamide (200 mg, 1.15 mmol) in ethanol (1 mL) was added potassium hydroxide solution (0.5M in ethanol, 2.5 mL). The mixture was stirred at room temperature for 1 hour and concentrated under reduced pressure to give the title compound as a pale orange crystal (quantitative yield).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b6648aef36af49e5980661e9e5859129
Source dataset
uspto-grants-2013_09
Patent number
US08536176B2

Reaction notes

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