Methyl iodide → HCID 46831341, compound

HRID 421531Notes

Reaction equation

HRID 421531 reaction equation
[S:1]([C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:15](=[O:16])[CH:14]=[C:13]([CH3:17])[NH:12]2)=[CH:7][CH:6]=1)([OH:4])(=[O:3])=[O:2].[CH3:18]I>CO>[S:1]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[C:15](=[O:16])[CH:14]=[C:13]([CH3:17])[N:12]2[CH3:18])=[CH:9][CH:10]=1)([OH:4])(=[O:2])=[O:3]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 15509271-(4-Sulfophenyl)-3-methyl-5-pyrazolone

Product 1

HCID 46831341HCID 46831341, compoundYield 44.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
130 °C

Procedure

3.0 g of 1-(4-sulfophenyl)-3-methyl-5-pyrazolone (manufactured by ALDRICH CHEMISTRY Co., Ltd.: 134163-25G), 3.4 g of methyl iodide (manufactured by KANTO CHEMICAL Co., Inc.: 10060), 100 mL of methanol were put in a high-pressure reactor, and stirred for 15 hours at 130° C. under heating. The reaction mixture was evaporated to dryness, and then recrystallized from ethanol to yield 1.4 g of a desired product.

Workup

  1. temperatureunder heating
  2. customThe reaction mixture was evaporated to dryness
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-868d8d86143a4a2b998c94c01c7ab1ba
Source dataset
uspto-grants-2012_01
Patent number
US08101374B2

Reaction notes

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