反应详情

A 842 mg portion of 4-(acetylamino)benzene sulfonyl chloride was added under ice-cooling to a pyridine solution (10 ml) of 3-(piperidin-2-yl)pyridine and stirred at room temperature for 2 hours. The solvent was concentrated under a reduced pressure, and the thus obtained residue was mixed with ethyl acetate and then washed with water, 1 M hydrochloric acid and saturated brine. This was dried with anhydrous sodium sulfate and then concentrated under a reduced pressure, and the thus obtained residue was purified by a silica gel column chromatography using chloroform:methanol (98:2) as the elution solvent, thereby obtaining 1.00 g of N-(4-{[2-(pyridin-3-yl)piperidin-1-yl]sulfonyl}phenyl)acetamide as a yellow foamy substance. FAB-MS (Pos): 360 [M+H]+.

1. concentrationThe solvent was concentrated under a reduced pressure
2. additionthe thus obtained residue was mixed with ethyl acetate
3. washwashed with water, 1 M hydrochloric acid and saturated brine
4. dry with materialThis was dried with anhydrous sodium sulfate
5. concentrationconcentrated under a reduced pressure
6. customthe thus obtained residue was purified by a silica gel column chromatography