Hydrochloric Acid → HCID 86629171, compound

Participants

Reaction Steps

Under ice-cooling, 296 mg of sodium hydride was added to an N,N-dimethylformamide solution (30 ml) of 1.99 g N-(3,4-dimethoxyphenyl)benzene sulfonamide and stirred at room temperature for 30 minutes, and then 0.75 ml of ethyl bromoacetate was added thereto and stirred for 2 hours. The reaction liquid was poured into ice water, acidified by adding 1 M hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with saturated brine, dried with anhydrous sodium sulfate and then concentrated under a reduced pressure. The thus obtained residue was purified by a silica gel column chromatography using ethyl acetate:n-hexane (1:2) as the elution solvent, thereby obtaining 2.47 g of ethyl [(3,4-dimethoxyphenyl)(phenylsulfonyl)amino]acetate as a pale yellow oily substance.

Provenance & Evidence