5-Propyl-2-bromopyrimidine → 2-[4-[2-(4-Methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]-5-propylpyrimidine

HRID 42156Notes

Reaction equation

HRID 42156 reaction equation
[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23](OCCCC)=O)[CH2:19][CH2:18]3)=[CH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH2:32]([C:35]1[CH:36]=[N:37]C(Br)=[N:39][CH:40]=1)[CH2:33][CH3:34]>>[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH:17]3[CH2:22][CH2:21][N:20]([C:23]4[N:39]=[CH:40][C:35]([CH2:32][CH2:33][CH3:34])=[CH:36][N:37]=4)[CH2:19][CH2:18]3)=[CH:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 104203465-Propyl-2-bromopyrimidineHCID 86654265HCID 86654265, compound

Product 1

HCID 670829052-[4-[2-(4-Methanesulfonylphenoxymethyl)pyridin-5-yl]piperidin-1-yl]-5-propylpyrimidine

Procedure

The title compound was prepared from tort-butyl 4-[2-(4-methanesulfonylphenoxymethyl)pyridin-5-yl]piperidine-1-carboxylate (Example 1) (50 mg, 0.11 mmol) and 5-propyl-2-bromopyrimidine (26 μL, 0.22 mmol) following a procedure analogous to that in Example 48 as a white crystal (31 mg, yield 60%).

Sources & evidence

ORD record
ord-bc2944d0219341cf8a778606ce857bfa
Source dataset
uspto-grants-2013_09
Patent number
US08536176B2

Reaction notes

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